A Chinese herbal decoction, Danggui Buxue Tang, activates extracellular signal-regulated kinase in cultured T-lymphocytes |
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| Authors: | Gao Qiu T Cheung Jerry K H Li Jun Jiang Zhi Y Chu Glanice K Y Duan Ran Cheung Anna W H Zhao Kui J Choi Roy C Y Dong Tina T X Tsim Karl W K |
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| Institution: | Department of Biology and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay Road, Hong Kong. |
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| Abstract: | Danggui Buxue Tang (DBT) is prepared from Radix Astragali and Radix Angelicae Sinensis. This Chinese herbal decoction has been shown to stimulate the proliferation of T-lymphocytes; however, the action mechanism of this stimulation has not been revealed. In cultured T-lymphocytes, application of DBT markedly induced the cell proliferation, the release of interleukin-2, -6 and -10, as well as the phosphorylation of extracellular signal-regulated kinases (ERK). The pre-treatment of ERK inhibitor blocked the DBT-induced immune responses. In addition, the polysaccharide-enriched fraction of DBT showed marked responses on the cultured T-lymphocytes suggesting the important role of DBT polysaccharide in triggering such immune responses. |
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| Keywords: | TCM Traditional Chinese medicine DBT Danggui Buxue Tang RA Radix Astragali RAS Radix Angelicae Sinensis ERK extracellular signal-regulated kinase |
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