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Pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1) |
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| Authors: | Purandare Ashok V Chen Zhong Huynh Tram Pang Suhong Geng Jieping Vaccaro Wayne Poss Michael A Oconnell Jonathan Nowak Kimberly Jayaraman Lata |
| Institution: | aBristol-Myers Squibb Pharmaceutical Research and Development, Princeton, NJ 08543, USA |
| Abstract: | This study reports the identification and Hits to Leads optimization of inhibitors of coactivator associated arginine methyltransferase (CARM1). Compound 7b is a potent, selective inhibitor of CARM1. |
| Keywords: | Coactivator associated arginine methyltransferase 1 CARM1 PRMT4 Protein arginine methyltransferase |
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