Formulation and Optimization of Orodispersible Tablets of Diazepam |
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Authors: | Khalid K Abed Ahmed A Hussein Mowafaq M Ghareeb Alaa A Abdulrasool |
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Institution: | (1) Department of Pharmaceutics, College of Pharmacy, Baghdad University, Baghdad, Iraq |
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Abstract: | Diazepam is one of the most prescribed benzodiazepines. The purpose of the present research was to optimize the formulation
of orodispersible tablets of diazepam. Orodispersible tablets of diazepam were prepared using different types of superdisintegrants
(Ac-Di-Sol, sodium starch glycolate, and crospovidone (CP)) and different types of subliming agents (camphor and ammonium
bicarbonate (AB)) at different concentrations and two methods of tablets preparations (wet granulation and direct compression
methods). The formulations were evaluated for flow properties, wetting time, hardness, friability, content uniformity, in vivo disintegration time (DT), release profiles, and buccal absorption tests. All formulations showed satisfactory mechanical
strength except formula F5 which contains camphor and formula F9 which is prepared by direct compression method. The results
revealed that the tablets containing CP as a superdisintegrant have good dissolution profile with shortest DT. The optimized
formula F7 is prepared using 10% CP as a superdisintegrant and 20% AB as a subliming agent by wet granulation method which
shows the shortest DT and good dissolution profile with acceptable stability. This study helps in revealing the effect of
formulation processing variables on tablet properties. It can be concluded that the orodispersible tablets of diazepam with
better biopharmaceutical properties than conventional tablets could be obtained using formula F7. |
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