Effect of lithium on hepatic drug-metabolizing enzymes of protein-deficient rats |
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Authors: | Aparna Tandon J P Nagpaul D K Dhawan |
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Institution: | (1) Department of Biochemistry, Panjab University, 160014 Chandigarh, India;(2) Department of Biophysics, Panjab University, 160014 Chandigarh, India |
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Abstract: | Protein deficiency was produced by feeding synthetic 8%-protein diet. Lithium carbonate at the dose level of 1.1g/kg diet
was administered to normal and protein-deficient rats for a period of one mo. A significant inhibition in the levels of cytochrome
(cyt) P450, cyt b5, glutathione (GSH), glutathione S-transferase (GST) and glutathione peroxidase (GPx), but an increase in γ-glutamyl transpeptidase
(γ-GT), was observed in low-protein LP-fed rats. Lithium treatment to normal rats caused no significant change in the activities
of cyt P450, cyt b5, GST, and GSH levels, whereas there was elevation in the activities of γ-GT and GPx and suppression in glutathione reductase
(GRd) activity. Lithium administration to LP-fed rats resulted in significant increases in the hepatic γ-GT and GPx activities. |
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Keywords: | Lithium low protein diet drug-metabolizing enzymes |
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