Analysis of mixed leucocyte culture (MLC) reactive cells after in vitro priming. Changes in avidity of T cell receptors. |
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| Authors: | R M Gorczynski M B Rittenberg |
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| Affiliation: | Imperial Cancer Research Fund, Tumour Immunology Unit, Department of Zoology, University College London, London WC1E 6BT, England |
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| Abstract: | Mixed leucocyte cultures were examined for populations of T cells responding to secondary stimulation with the priming antigen. Two such populations are described, one of which is stimulated optimally by low, the other by high doses of antigen. Both cell populations are sensitive to anti brain θ serum and complement, but are physically separable by size and by adherence on macrophage monolayers. The anti-brain θ-sensitive population stimulated by low antigen doses consists of larger cells with immunoglobulin-moieties on their surfaces. |
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| Keywords: | Author to whom correspondence should be directed. Present address: Ontario Cancer Institute Toronto 5 Ontario Canada. |
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