Regeneration of midgut epithelial cell in the silkworm, Bombyx mori, infected with viruses |
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Authors: | Hajime Inoue Masamichi Miyagawa |
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Institution: | 1. Sericultural Experiment Station, Wada, Suginami-ku, Tokyo 166, Japan;2. Niigataken Sericultural Experiment Station, Ushikajima, Kawaguchi, Kitauonuma, Niigata 949-75, Japan |
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Abstract: | In the larvae of the silkworm, Bombyx mori, the regeneration of midgut cells infected with a cytoplasmic polyhedrosis virus (CPV), a flacherie virus (FV), and a small DNA virus (SDV) was studied. Large numbers of newly developed cells appeared in the CPV-infected part of the midgut epithelium just before larval molt, and along with their development, the CPV-infected old columnar cells were discharged into the midgut lumen during the molt. On the other hand, in the uninfected portion of the midgut only a few cells developed, and no columnar cells were discharged. Similarly, the marked replacement of midgut epithelial cells during larval molt was also observed in larvae infected with CPV + FV. In the larvae infected with CPV + SDV, the columnar cells lost their regenerative ability, and because of the exfoliation of infected columnar cells, the midgut epithelium consisted mainly of uninfected goblet cells at a late stage of infection. The degree of epithelial regeneration varied with the silkworm strain and the dosage of the virus. |
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Keywords: | cytoplasmic polyhedrosis virus flacherie virus small DNA virus cell regeneration insect immunity |
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