Cyclic nucleotide phosphodiesterases in larval brain of wild type and dunce mutant strains of Drosophila melanogaster: isoenzyme pattern and activation by Ca2+/calmodulin |
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| Authors: | M Solti P Dévay I Kiss J Londesborough P Friedrich |
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| Affiliation: | 1. Institute of Enzymology, Biological Research Center, Szeged, Hungary;2. Institute of Genetics, Biological Research Center, Szeged, Hungary;3. Hungarian Academy of Sciences, Budapest, P.O. Box 7, H-1502 Hungary;4. Research Laboratories of the State Alcohol Monopoly, Box 350, SF-00101 Helsinki 10, Finland |
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| Abstract: | ![]()
Like adult heads and whole flies, larval brains of wild type Drosophila melanogaster contain two major soluble cyclic nucleotide phosphodiesterases, forms I and II. Larval brains of the learning-defective mutant strain, dunceM11, contain only the form I enzyme. In both wild type and dunce strains the form I enzyme is activated by Ca2+/calmodulin. A time-dependent loss of this Ca2+ activation was observed. |
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| Keywords: | EGTA ethyleneglycol bis(β-aminoethyl ether)-N N′-tetraacetic acid |
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