Ornithine uptake by isolated hepatocytes and distribution within the cell |
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| Authors: | H Zollner |
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| Affiliation: | 2. Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, California, USA;3. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA;4. Department of Integrative Biology, University of California, Berkeley, Berkeley, California, USA;5. QB3 Institute, University of California, Berkeley, Berkeley, California, USA |
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| Abstract: | Uptake of ornithine by isolated hepatocytes and its distribution within the cell was investigated. Ornithine uptake was energy independent and exhibited a saturable and a nonsaturable component. The Km value of the saturable component was 1.3 mM. At an external ornithine concentration of 0.5 mM the rate of ornithine uptake was 127 +/- 19 nmol/g. Lysine inhibited ornithine uptake, indicating the existence of an ornithine transport system. It was concluded that ornithine transport can limit urea synthesis in the state of transition from a low ammonia to a high ammonia supply. |
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