Effect of overdose zinc on mouse testis and its relation with sperm count and motility |
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| Authors: | Güfer Turgut Gücin Abban Sabahat Turgut Günur Take |
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| Institution: | (1) Department of Physiology, Faculty of Medicine, Pamukkale University, 2020 Kinikli, Denizli, Turkey;(2) Department of Histology and Embryology, Faculty of Medicine, Pamukkale University, 2020 Kinikli, Denizli, Turkey;(3) Department of Histology and Embryology, Faculty of Medicine, Baskent University, Bagcali, Ankara, Turkey |
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| Abstract: | The purpose of this study was to investigate the effects of excessive zinc intake on the testes and on sperm count and motility
in mice. Thirty Balb c mice were divided randomly into 3 groups of 10 animals in each. Group I acted as controls; group II
was supplied with drinking water containing 1.5 g/100 mL Zn, and group III was supplied with drinking water containing 2.5
g/100 mL Zn. The animals were sacrificed after 3 wk supplementation and the epididymis and testis were quickly excised. A
negative correlation between Zn dose and sperm count and motility was found. The sperm count in group III was significantly
lower than in groups II and I (p<0.05). The sperm motility in group III was significantly lower than in the controls (p<0.05). Degenerative changes, including spermatic arrest, degeneration of seminiferous tubules, and fibrosis in interstitial
tissue, were observed in group III animals. These results show that high doses of zinc significantly alter sperm motility. |
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| Keywords: | Zinc sperm count sperm motility testis mouse histopathology |
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