A comparison of the in vitro antimicrobial activity of liposomes containing meropenem and gentamicin |
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| Authors: | Zuzanna Drulis-Kawa Jerzy Gubernator Agata Dorotkiewicz-Jach Włodzimierz Doroszkiewicz Arkadiusz Kozubek |
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| Institution: | (1) Institute of Genetics and Microbiology, University of Wrocław, Przybyszewskiego 63/77, 51-148 Wrocław, Poland;(2) Institute of Biochemistry and Molecular Biology, University of Wrocław, 51-148 Wrocław, Poland;(3) Lower Silesian Centre of Paediatrics in Wrocław, 51-147 Wrocław, Poland;(4) Academic Centre for Biotechnology of Supramolecular Lipid Aggregates, 51-148 Wrocław, Poland |
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| Abstract: | The antimicrobial activity of eight cationic, two neutral and three anionic liposome compositions containing meropenem and
gentamicin was tested in vitro in broth and serum medium. The cationic formulations showed better antibacterial efficacy against both Gram-positive and
Gram-negative bacteria than the anionic and neutral ones, regardless of the encapsulated drug. The most effective formulations
were the cationic PC/DOPE/DOTAP 3:4:3 and PC/Chol/DOTAP 3:4:3, as the MICs with meropenem were 2 to 4 times lower than those
of the free drug. |
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| Keywords: | Liposomes Meropenem Gentamicin Bacteria |
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