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Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease
Authors:Evgeniia Prokhorova  Thomas Agnew  Anne R. Wondisford  Michael Tellier  Nicole Kaminski  Danique Beijer  James Holder  Josephine Groslambert  Marcin J. Suskiewicz  Kang Zhu  Julia M. Reber  Sarah C. Krassnig  Luca Palazzo  Shona Murphy  Michael L. Nielsen  Aswin Mangerich  Dragana Ahel  Jonathan Baets  Ivan Ahel
Affiliation:1. Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK;2. Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA;3. Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium;4. Laboratory of Neuromuscular Pathology, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium;5. Molecular Toxicology Group, Department of Biology, University of Konstanz, 78457 Konstanz, Germany;6. Neuromuscular Reference Centre, Department of Neurology, Antwerp University Hospital, Antwerp, Belgium;7. Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark
Abstract:
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  • Keywords:DNA damage  chromatin  ADP-ribosylation  ARH3/ADPRHL2  PARG  BRCA  telomere  neurodegeneration  cancer  PARP inhibitor
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