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Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets
Authors:Rui Liu  Jong-Ho Lee  Jingyi Li  Rilei Yu  Lin Tan  Yan Xia  Yanhua Zheng  Xue-Li Bian  Philip L. Lorenzi  Qianming Chen  Zhimin Lu
Affiliation:1. Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, 310029, China;2. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China;3. Department of Health Sciences, The Graduate School of Dong-A University, Busan, 49315, Republic of Korea;4. Department of Biological Sciences, Dong-A University, Busan 49315, Republic of Korea;5. The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan, 610051, China;6. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003, China;7. The Proteomics and Metabolomics Core Facility, Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA;8. Department of Neuro-Oncology and Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;9. The Affiliated Hospital of Qingdao University, Qingdao Cancer Institute, Qingdao, Shandong 266071, China;10. Stomatology Hospital, School of Stomatology, Cancer Center, Zhejiang University School of Medicine, and Key Laboratory of Oral Biomedical Research of Zhejiang Province, Clinical Research Center of Oral Diseases of Zhejiang Province, Hangzhou, 310006, Zhejiang, China;11. Zhejiang University Cancer Center, Hangzhou, 310029, China
Abstract:
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  • Keywords:choline kinase  PLIN2/3  AMPK  KAT5  lipid droplet  lipolysis  autophagy  phosphorylation  acetylation  tumorigenesis
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