Phytochemical screening and anti-oxidant activity of Sargassum wightii enhances the anti-bacterial activity against Pseudomonas aeruginosa |
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Authors: | Govindan Nadar Rajivgandhi Chelliah Chenthis Kanisha Govindan Ramachandran Natesan Manoharan Ramzi A Mothana Nasir A Siddiqui Adnan J Al-Rehaily Riaz Ullah Omer M Almarfadi |
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Institution: | 1. Department of Marine Science, Bharathidasan University, Tiruchirappalli 620024, Tamil Nadu, India;2. Noorul Islam Centre for Higher Education, Kumaracoil, Kanyakumari, Tamil Nadu 629180, India;3. Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia |
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Abstract: | In this study, the phytochemical, phenolic, flavonoid and bioactive compounds were successfully screened from crude extract of Sargassum wightii by LC-MS analysis after NIST interpretation. Bacterial growth inhibition study result was shown with 24 mm zone inhibition at 200 µg/mL concentration against P. aeruginosa. The increased phenolic content was much closed to gallic acid and the range was observed at 250 μg/mL concentration. In addition, flavonoid contents of the algae extract was indicated more significant with rutin at 200 μg/mL. In result, both the phenolic and flavonoid contents of the extract were more correlated with gallic acid and rutin. Further, the total anti-oxidant and DPPH radical scavenging activities were shown increased activity at 200 μg/mL concentrations. Furthermore, the excellent anti-bacterial alteration result was observed at 200 μg/mL concentration by minimum inhibition concentration. Therefore, the result was revealed that the marine algae Sargassum wightii has excellent phytochemical and anti-oxidant activities, and it has improved anti-bacterial activity against P. aeruginosa. |
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Keywords: | Marine algae Phytochemical compounds Anti-oxidant properties Bacterial inactivation and minimum inhibition concentration |
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