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Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML
Authors:Simone S. Riedel  Congcong Lu  Hongbo M. Xie  Kevin Nestler  Marit W. Vermunt  Alexandra Lenard  Laura Bennett  Nancy A. Speck  Ichiro Hanamura  Julie A. Lessard  Gerd A. Blobel  Benjamin A. Garcia  Kathrin M. Bernt
Affiliation:1. Division of Pediatric Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA;2. Department of Biochemistry and Biophysics, University of Pennsylvania, and the Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;3. Department of Bioinformatics and Health Informatics (DBHI), Children’s Hospital of Philadelphia, Philadelphia, PA, USA;4. Division of Hematology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA;5. Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;6. Division of Hematology, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan;7. Department of Pathology and Cell Biology, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada;8. Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania and Abramson Cancer Center, Philadelphia, PA, USA
Abstract:
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  • Keywords:Meningioma-1  BAF  SWI/SNF  leukemia  AML  IDP  polyQ  IDR  intrinsically disordered protein/region
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