Amino acid-based enantiomerically pure 3-substituted 1,4-benzodiazepin-2-ones: a new class of anti-ischemic agents |
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Authors: | Mishra Jitendra Kumar Garg Puja Dohare Preeti Kumar Ashutosh Siddiqi Mohammad Imran Ray Madhur Panda Gautam |
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Institution: | Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, UP, India. |
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Abstract: | A series of 3-substituted 1,4-benzodiazepin-2-ones derived from S and R amino acids were evaluated for their anti-ischemic activity in vitro. Treatment with compounds 7h, 16, 9d, and 17 decreased the apoptotic neuronal number, however increased the neuronal viability. The compounds decreasing apoptosis could protect neurons from the ischemic injury. The difference in the activities of 1,4-benzodiazepin-2-ones derived from S- and R-amino acids is discussed and explained on the basis of molecular modeling studies. |
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