| Caspase-9选择性剪切及其在非小细胞肺癌治疗中的应用 |
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| 引用本文： | 匡彦蓓,李 萍,李 强.Caspase-9选择性剪切及其在非小细胞肺癌治疗中的应用[J].生物化学与生物物理进展,2017,44(4):293-302. |
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| 作者姓名： | 匡彦蓓 李 萍 李 强 |
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| 作者单位： | 中国科学院近代物理研究所，兰州 730000；中国科学院重离子束辐射生物医学重点实验室，兰州 730000；甘肃省重离子束辐射医学应用基础重点实验室，兰州 730000；中国科学院大学，北京 100049,中国科学院近代物理研究所，兰州 730000；中国科学院重离子束辐射生物医学重点实验室，兰州 730000；甘肃省重离子束辐射医学应用基础重点实验室，兰州 730000,中国科学院近代物理研究所，兰州 730000；中国科学院重离子束辐射生物医学重点实验室，兰州 730000；甘肃省重离子束辐射医学应用基础重点实验室，兰州 730000 |
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| 基金项目： | 国家自然科学基金重点项目(U1232207)，国家自然科学基金青年基金(11305223)，科技部重点研发计划 (2016YFC0904700)和国家科技支撑计划重点项目 (2015BAI01B11)资助 |
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| 摘 要： | 越来越多的证据指出前体mRNA选择性剪切的调节在癌症病理生理学上的重要性.在非小细胞肺癌(NSCLC)的发生及发展中caspase-9 mRNA的选择性剪切发挥着重要作用,caspase-9的2个剪切异构体caspase-9a和caspase-9b的比值与NSCLC肿瘤的发生和维持密切相关,并且调节该比值关系会影响到NSCLC细胞对于抗癌治疗的敏感性.因此,caspase-9的选择性剪切是目前NSCLC治疗和诊断最受关注的焦点.本文就caspase-9的选择性剪切及其在NSCLC治疗中的应用展开综述.
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| 关 键 词： | caspase-9，选择性剪切，capase-9a/9b，非小细胞肺癌，化学药物治疗，敏感性 |
| 收稿时间： | 2016/9/6 0:00:00 |
| 修稿时间： | 2017/2/27 0:00:00 |
The Alternative Splicing of Caspase-9 and Its Application in Therapy of NSCLC |
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| KUANG Yan-Bei,LI Ping and LI Qiang.The Alternative Splicing of Caspase-9 and Its Application in Therapy of NSCLC[J].Progress In Biochemistry and Biophysics,2017,44(4):293-302. |
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| Authors: | KUANG Yan-Bei LI Ping and LI Qiang |
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| Institution: | Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China; Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Gansu Province, Lanzhou 730000, China; University of Chinese Academy of Sciences, Beijing 100049, China,Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China; Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Gansu Province, Lanzhou 730000, China and Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China; Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Gansu Province, Lanzhou 730000, China |
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| Abstract: | Mounting evidence indicates the functional importance of alternative splice variations in cancer pathophysiology. The alternative splicing of caspase-9 plays an important role in non-small cell lung cancer (NSCLC). The splicing of caspase-9 gene generates two isoforms caspase-9a and caspase-9b, the ratio of caspase-9a/9b mRNA is pretty lower in a large proportion of human NSCLC tumors. A low caspase-9a/9b ratio, demanded for the tumorigenecity of NSCLC cells, is correlated with the sensitivity of NSCLC cells to anticancer therapy. Thus, the alternative splicing of caspase-9 suggests a novel and crucial distal mechanism in NSCLC and offers promise of a new target for the development of therapeutics in the defense against cancers. Therefore, this review is to summarize the alternative splicing of caspase-9 and its application in the therapy of NSCLC. |
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| Keywords: | caspase-9 alternative splicing caspase-9a/9b NSCLC chemotherapy sensitivity |
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