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Linkage analysis of the Duffy blood group marker with several chromosome 1 genes in an extended pedigree with Charcot-Marie-Tooth disease |
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| Authors: | Peter Raeymaekers Christine Van Broeckhoven Hubert Backhovens Anita Wehnert Ludo Muylle Peter De Jonghe Jan Ghenens Jean-Jacques Martin Antoon Vandenberghe |
| Institution: | (1) Department of Biochemistry, University of Antwerpen, U.I.A., Universiteitsplein 1, B-2610 Antwerpen, Belgium;(2) Department of Medicine, University of Antwerpen, U.I.A., Universiteitsplein 1, B-2610 Antwerpen, Belgium;(3) Innogenetics, Industriepark Zwijnaarde, B-9000 Gent, Belgium |
| Abstract: | Summary We have recently demonstrated tight linkage of the Duffy blood group marker to the  -spectrin gene in an extended pedigree with Charcot-Marie-Tooth neuropathy. To determine a more precise location of the Duffy blood group locus on the chromosome 1 map we have tested several more chromosome 1 genes for linkage with this marker. We found suggestive linkage with the antithrombin III and apolipoprotein A2 genes and conclusive linkage with the gene coding for  -nerve growth factor. |
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