Influence of power-law rheology on cell injury during microbubble flows |
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Authors: | H L Dailey S N Ghadiali |
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Institution: | (1) Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA;(2) Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA;(3) Medical Engineering Design and Innovation Centre, Cork Institute of Technology, Bishopstown, Co, Cork, Ireland |
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Abstract: | The reopening of fluid-occluded pulmonary airways generates microbubble flows which impart complex hydrodynamic stresses to
the epithelial cells lining airway walls. In this study we used boundary element solutions and finite element techniques to
investigate how cell rheology influences the deformation and injury of cells during microbubble flows. An optimized Prony–Dirichlet
series was used to model the cells’ power-law rheology (PLR) and results were compared with a Maxwell fluid model. Results
indicate that membrane strain and the risk for cell injury decreases with increasing channel height and bubble speed. In addition,
the Maxwell and PLR models both indicate that increased viscous damping results in less cellular deformation/injury. However,
only the PLR model was consistent with the experimental observation that cell injury is not a function of stress exposure
duration. Correlation of our models with experimental observations therefore highlights the importance of using PLR in computational
models of cell mechanics/deformation. These computational models also indicate that altering the cell’s viscoelastic properties
may be a clinically relevant way to mitigate microbubble-induced cell injury. |
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