Dual role of nNOS in ischemic injury and preconditioning |
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| Authors: | Anupama Barua Nicholas B Standen Manuel Galiñanes |
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| Affiliation: | 1.Cardiac Surgery Unit, Dept. of Cardiovascular Sciences,University of Leicester,UK;2.Dept. Cell Physiology & Pharmacology,University of Leicester,UK;3.Department of Cardiac Surgery, Area del Cor (ACOR) and Research Institute,University Hospital Vall d'Hebron, Universitat Autònoma de Barcelona,Barcelona,Spain |
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| Abstract: | Background Nitric oxide (NO) is cardioprotective and a mediator of ischemic preconditioning (IP). Endothelial nitric oxide synthase (eNOS) is protective against myocardial ischemic injury and a component of IP but the role and location of neuronal nitric oxide synthase (nNOS) remains unclear. Therefore, the aims of these studies were to: (i) investigate the role of nNOS in ischemia/reoxygenation-induced injury and IP, (ii) determine whether its effect is species-dependent, and (iii) elucidate the relationship of nNOS with mitoKATP channels and p38MAPK, two key components of IP transduction pathway. |
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