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A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function |
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| Authors: | Chambers Robert J Abrams Kristin Castleberry Tessa A Cheng John B Fisher Douglas A Kamath Ajith V Marfat Anthony Nettleton David O Pillar Joann D Salter Eben D Sheils Alissa L Shirley John T Turner Claudia R Umland John P Lam Kelvin T |
| Affiliation: | Groton Laboratories, Pfizer, Inc., Eastern Point Road, Groton, CT 06340, USA. Robert.J.Chambers@pfizer.com |
| Abstract: | Nicotinamide (2) is a potent and selective inhibitor of the PDE4D isozyme and as a chemical tool selectively blocks eosinophil mediator release and chemotaxis thus linking the role of PDE4D to eosinophil function. |
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