Astrocyte–neuron interactions in neurological disorders |
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Authors: | G Ricci L Volpi L Pasquali L Petrozzi G Siciliano |
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Institution: | (1) Neurologic Clinic, University of Pisa, Pisa, Italy |
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Abstract: | Astrocytes have long been considered as just providing trophic support for neurons in the central nervous system, but recently
several studies have highlighted their importance in many functions such as neurotransmission, metabolite and electrolyte
homeostasis, cell signaling, inflammation, and synapse modulation. Astrocytes are, in fact, part of a bidirectional crosstalk
with neurons. Moreover, increasing evidence is stressing the emerging role of astrocyte dysfunction in the pathophysiology
of neurological disorders, including neurodegenerative disease, stroke, epilepsy, migraine, and neuroinflammatory diseases. |
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Keywords: | Astrocytes Neurological diseases Neurodegeneration Glial cells |
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