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First detection, isolation and molecular characterization of infectious salmon anaemia virus associated with clinical disease in farmed Atlantic salmon (Salmo salar) in Chile |
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| Authors: | Marcos G Godoy Alejandra Aedo Molly JT Kibenge David B Groman Carmencita V Yason Horts Grothusen Angelica Lisperguer Marlene Calbucura Fernando Avendaño Marcelo Imilán Miguel Jarpa Frederick SB Kibenge |
| Affiliation: | 1. Biovac SA, Puerto Montt, Chile 2. Department of Pathology and Microbiology, OIE Reference Laboratory for ISA, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada 3. Aquatic Diagnostic Services, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada 4. Regional Diagnostic Virology Laboratory, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, PE, Canada 5. Marine Harvest S.A., Puerto Montt, Chile |
| Abstract: | BackgroundSeveral forms of progressive retinal atrophy (PRA) segregate in more than 100 breeds of dog with each PRA segregating in one or a few breeds. This breed specificity may be accounted for by founder effects and genetic drift, which have reduced the genetic heterogeneity of each breed, thereby facilitating the identification of causal mutations. We report here a new form of PRA segregating in the Border Collie breed. The clinical signs, including the loss of night vision and a progressive loss of day vision, resulting in complete blindness, occur at the age of three to four years and may be detected earlier through systematic ocular fundus examination and electroretinography (ERG). |
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