Essential and distinct roles of the F-box and helicase domains of Fbh1 in DNA damage repair |
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Authors: | Chikako Sakaguchi Takashi Morishita Hideo Shinagawa Takashi Hishida |
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Institution: | (1) Laboratory of Genome Dynamics, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan;(2) BioAcademia Inc., Ibaraki Osaka, 565-0085, Japan |
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Abstract: | Background DNA double-strand breaks (DSBs) are induced by exogenous insults such as ionizing radiation and chemical exposure, and they
can also arise as a consequence of stalled or collapsed DNA replication forks. Failure to repair DSBs can lead to genomic
instability or cell death and cancer in higher eukaryotes. The Schizosaccharomyces pombe fbh1 gene encodes an F-box DNA helicase previously described to play a role in the Rhp51 (an orthologue of S. cerevisiae RAD51)-dependent recombinational repair of DSBs. Fbh1 fused to GFP localizes to discrete nuclear foci following DNA damage. |
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