The contribution of N-glycans and their processing in the endoplasmic reticulum to glycoprotein biosynthesis |
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| Authors: | Trombetta E Sergio |
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| Affiliation: | Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, PO Box 208002, New Haven, CT 06520, USA. sergio.trombetta@yale.edu |
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| Abstract: | ![]()
The attachment of N-glycans to nascent glycoproteins in the endoplasmic reticulum (ER) is intimately related to glycoprotein biogenesis. Processing of N-linked oligosaccharides begins in the ER and participates in glycoprotein folding and assembly. The elucidation of N-glycan processing mechanisms in the ER is uncovering their role in glycoprotein biosynthesis. |
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