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Genetic Control of Variable and Constant Regions of Immunoglobulin Heavy Chains
Authors:ROSE G. MAGE  GLENDOWLYN O. YOUNG-COOPER  CORNELIUS ALEXANDER
Affiliation:1.Laboratory of Immunology,National Institute of Allergy and Infectious Diseases, National Institutes of Health,Bethesda
Abstract:IMMUNOGLOBULIN polypeptide chains consist of two well defined regions designated the “variable region” and the “constant region”. Whereas great diversity exists in amino-acid sequences of variable regions, the constant regions of a given subclass of heavy chains (CH)* are essentially invariant in sequence1, 2. Exceptions are the allelic forms, such as the rabbit allotypes A14 and A153, 4, where a threonine-alanine interchange occurs in the constant region of γ chains (Appella, Chersi, R. G. M. and Dubiski, in preparation). The markers unique to a chains (for example, A14-A15) are closely linked to allotypic markers at the a locus (a1, a2, a3)3, 4 which seem to be present on four different Ig heavy chain classes (α, γ, ε, µ)5–7. These puzzling observations can be explained if the a locus determinants are variable region markers which reflect genetically controlled differences in some relatively constant residues within the VH region sequences7.
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