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D-amino acid oxidase: structure,catalytic mechanism,and practical application
Authors:V.?I.?Tishkov  author-information"  >  author-information__contact u-icon-before"  >  mailto:vit@enz.chem.msu.ru   tishkov@pochta.ru"   title="  vit@enz.chem.msu.ru   tishkov@pochta.ru"   itemprop="  email"   data-track="  click"   data-track-action="  Email author"   data-track-label="  "  >Email author,S.?V.?Khoronenkova
Affiliation:(1) Department of Chemical Enzymology, Faculty of Chemistry, Lomonosov Moscow State University, 119992 Moscow, Russia
Abstract:D-Amino acid oxidase (DAAO) is a FAD-dependent enzyme that plays an important role in microbial metabolism, utilization of endogenous D-amino acids, regulation of the nervous system, and aging in mammals. DAAO from yeasts Rhodotorula gracilis and Trigonopsis variabilis are used to convert cephalosporin C into 7-aminocephalosporanic acid, the precursor of other semi-synthetic cephalosporins. This review summarizes the recent data on the enzyme localization, physiological role, gene cloning and expression, and the studies on the enzyme structure, stability, catalytic mechanism, and practical applications.Translated from Biokhimiya, Vol. 70, No. 1, 2005, pp. 51–67.Original Russian Text Copyright © 2005 by Tishkov, Khoronenkova.
Keywords:D-amino acid oxidase  cloning  expression  stability  protein engineering  Trigonopsis variabilis  Rhodotorula gracilis
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