Conversion of methionine to homocysteine thiolactone in liver |
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| Authors: | Eliot Spindel Kilmer S. McCully |
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| Affiliation: | 1. Department of Pathology, Harvard Medical School, U.S.A.;2. James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, Mass. 02114 U.S.A. |
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| Abstract: | ![]()
Since hemocysteinemia is associated with arteriosclerosis, the conversion of methione to homocysteine thiolactone was studied in guinea pig liver in vivo. 60 min after intraperitoneal injection of [14C]methione, [14C]homocystein thiolactone was found to constitute 9.1% ± 0.2 of the lipid bound 14C and 20% ± 1.0 of the acid soluble 14C. This conversion is the first step of a new pathway by which the sulfur of methionine is transferred to phosphoadenosine phosphosulfate. |
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| Keywords: | Address correspondence to Kilmer S. McCully M.D. Department of Pathology Massachusetts General Hospital Boston Mass. 02114 U.S.A. |
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