Resistance of multidrug-resistant lines to natural killer-like cell-mediated cytotoxicity |
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Authors: | G Woods L A Lund M Naik V Ling A Ochi |
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Institution: | Department of Immunology, Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada. |
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Abstract: | Multidrug resistance (MDR) refers to a complex phenotype that describes a number of features characterized primarily by resistance to a wide range of structurally unrelated drugs. In this paper we investigated the relationship between drug resistance and resistance to NK-mediated cytotoxicity. Studies with two independently selected multidrug-resistant cell lines indicated that increased drug resistance was associated with both an increased resistance to NK-mediated cytotoxicity and increased levels of membrane P-glycoprotein expression. This resistance to cytotoxicity appears to result partly from an alteration in the membrane structure of the target cells inasmuch as there was a reduction in effector:target cell recognition. Resistance to NK-mediated cytotoxicity should be included with the numerous pleiotropic changes associated with the multidrug resistance phenotype. |
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