|
|||||
|
|
Myrothins A–F from Endophytic Fungus Myrothecium sp. BS-31 Harbored in Panax notoginseng |
|
| Authors: | Deng-Sen Xiong Ya-Bin Yang Bin-Yuan Hu Cui-Ping Miao Yong-Liang Wang Jin-Mei Zou Lei Li Yi-Qing Li Xiao-Dong Luo Li-Xing Zhao |
| Institution: | 1. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Research and Development Center for Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming, 650091 P. R. China
Yunnan Institute of Microbiology, Yunnan University, Kunming, 650091 P. R. China These authors contributed equally to this work.;2. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Research and Development Center for Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming, 650091 P. R. China These authors contributed equally to this work.;3. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Research and Development Center for Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming, 650091 P. R. China;4. Yunnan Institute of Microbiology, Yunnan University, Kunming, 650091 P. R. China;5. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Research and Development Center for Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming, 650091 P. R. China Yunnan Institute of Microbiology, Yunnan University, Kunming, 650091 P. R. China |
| Abstract: | Endophytic fungi play important roles for host's stress tolerance including invasion by pathogenic microbes. Small molecules are common weapons in the microbe–microbe interactions. Panax notoginseng is a widely used traditional Chinese medicinal plant and harbors many endophytes, some exert functions against pathogens. Here, we report six new compounds named myrothins A–F ( 1 – 6 ) produced by Myrothecium sp. BS-31, an endophyte isolated from P. notoginseng, and their antifungal activities against pathogenic fungi causing host root-rot disease. Their structures were elucidated with analysis of spectroscopic data including 1D and 2D NMR, HR-ESI-MS. Myrothins B ( 2 ) and E ( 5 ) showed the weak activity against Fusarium oxysporum and Phoma herbarum, and myrothins F ( 6 ) showed weak activity against F. oxysporum. |
| Keywords: | Myrothecium Panax notoginseng myrothins A–F antifungal activity |