|
|||||
|
|
Three Previously Undescribed Chlorophenyl Glycosides from the Bulbs of Lilium regale |
|
| Authors: | Jie Yan Wenxiu Guo Lanyu Zhou Dale Guo Jin Pei Yun Deng Haoyuan Zheng Ding Liu Xiaofang Xie Cheng Peng |
| Institution: | 1. State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137 P. R. China
College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137 P. R. China Chengdu Push Bio-technology Co., Ltd., Chengdu, 610000 P. R. China Jie Yan and Wenxiu Guo contributed equally to this work.;2. College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137 P. R. China Jie Yan and Wenxiu Guo contributed equally to this work.;3. College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137 P. R. China;4. State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137 P. R. China College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137 P. R. China;5. Chengdu Push Bio-technology Co., Ltd., Chengdu, 610000 P. R. China;6. State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137 P. R. China |
| Abstract: | Three previously undescribed chlorophenyl glycosides, (2,4,6-trichloro-3-hydroxy-5-methoxyphenyl)methyl β-D-glucopyranoside ( 1 ), (2,4-dichloro-3,5-dimethoxyphenyl)methyl 6-O-β-D-glucopyranosyl-β-D-glucopyranoside ( 2 ) and 4-chloro-3-methoxy-5-methylphenyl 6-O-(6-deoxy-β-L-mannopyranosyl)-β-D-glucopyranoside ( 3 ) were obtained from Lilium regale. The absolute configurations of these new finds were elucidated by comprehensive analyses of spectroscopic data combined with acid hydrolysis derivatization. (2,4-dichloro-3,5-dimethoxyphenyl)methyl 6-O-β-D-glucopyranosyl-β-D-glucopyranoside ( 2 ) can inhibit the proliferation of lung carcinoma A549 cells with an IC50 value of 29 μΜ. |
| Keywords: | Lilium regale chlorophenyl glycosides structural elucidation anti-proliferative activity |