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Application of nanoparticles in cancer therapy with an emphasis on cell cycle |
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| Authors: | Hossein Ghahramani Almanghadim Zahra Nourollahzadeh Nazanin Sadat Khademi Masoud Dehghan Tezerjani Fatemeh Zeinali Sehrig Neda Estelami Milad Shirvaliloo Roghayeh Sheervalilou Saman Sargazi |
| Institution: | 1. Department of Molecular Genetics, Ahar Branch, Islamic Azad University, Ahar, Iran;2. Department of Biological Science, Ahar Branch, Islamic Azad University, Ahar, Iran;3. Department of Genetics, Faculty of Biological Science, Shahid Beheshti University, Tehran, Iran;4. Abortion Research Centre, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Science, Yazd, Iran;5. Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;6. Pharmacology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran;7. Cellular and Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran |
| Abstract: | Owing to their unique characteristics, nanoparticles (NPs) could be incorporated into valuable therapeutic modalities for different diseases; however, there are many concerns about risk factors in human applications. NPs carry therapeutic chemicals that could improve the outcome of cancer therapies. Nowadays, NPs are being recognized as important and strategic agents in treatment of several disorders due to their unique properties in targeting malignant cells in tumor sites. Numerous investigations have shown that the majority of chemotherapeutic agents can be modified through entrapment in submicron colloidal systems. Still, there are problems and limitations in application of NPs in cancer therapy. The aim of the present study is to focus on potential NPs usage in cancer treatment with an emphasis on the cell cycle of malignant cells. |
| Keywords: | cancer therapy cell cycle nanoparticles (NPs) |