| Affiliation: | 1. Programa de Pós-graduação em Ambiente e Sustentabilidade, Universidade Estadual do Rio Grande do Sul (UERGS) – Campus Hortênsias, Rua Assis Brasil, No. 842, Centro, CEP, 95400-000 São Francisco de Paula, RS, Brazil;2. Universidade Federal do Rio Grande – Campus Santo Antônio da Patrulha (FURG/SAP), Rua Coronel Francisco Borges de Lima, 3005, Bairro Bom Princípio, CEP, 955900-000 Santo Antônio da Patrulha, RS, Brazil;3. Universidade de Caxias do Sul – Campus Sede, Rua Francisco Getúlio Vargas, 1130, Bairro Petrópolis, CEP, RS 95070-560 Caxias do Sul, Brazil;4. Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul – Campus Porto Alegre (IFRS/POA), Rua Cel. Vicente, 281, Bairro Centro Histórico, CEP, 90030-041 Porto Alegre, RS, Brazil;5. Universidade Federal de Roraima – Campus do Paricarana, Av. Cap. Enê Garcêz, 2413, Bloco III, Aeroporto, CEP, 69310-000 Paricarana, RR, Brazil;6. Programa de Pós-graduação em Ambiente e Sustentabilidade, Universidade Estadual do Rio Grande do Sul (UERGS) – Campus Hortênsias, Rua Assis Brasil, No. 842, Centro, CEP, 95400-000 São Francisco de Paula, RS, Brazil Universidade Estadual do Rio Grande do Sul – Campus Litoral Norte (UERGS/LN), Rua Machado de Assis, No. 1456, Sulbrasileiro, CEP, 95520-000 Osório, RS, Brazil |
| Abstract: | The present study aimed to determine the chemical composition and biological activity of the essential oil obtained from Phyllogonium viride Brid. (Phyllogoniaceae, Bryophyta), whose samples were collected in southern Brazil. For the first time, the cytotoxic activity of the essential oil of P. viride in breast and colorectal tumor cells (MCF-7 and HCT-116) was evaluated, as well as the cytotoxic potential of this oil in non-tumoral cells of human immortalized keratinocytes (HaCaT) via MTT assay. The compounds majorly found in P. viride essential oil were β-bazzanene (20.30 %), β-caryophyllene (17.06 %), β-chamigrene (14.02), and germacrene B (11.72 %). Treatment with P. viride essential oil in the different tested cell lines did not induce any toxicity in most of the tested concentrations. These data contribute to generating new scientific information about this understudied plant species. Furthermore, the chemical characterization of the compounds present in the essential oil of P. viride can lead to greater elucidation of its biotechnological potential. |
