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Single in-line biomass probe detects CHO cell growth by capacitance and bacterial contamination by conductivity in bioreactor |
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| Authors: | Caitlin Morris Chikkathur N. Madhavarao Seongkyu Yoon Muhammad Ashraf |
| Affiliation: | 1. Department of Chemical Engineering, University of Massachusetts, Lowell, Lowell, Massachusetts, USA Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA Caitlin Morris and Chikkathur N. Madhavarao contributed equally to this study.;2. Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA Caitlin Morris and Chikkathur N. Madhavarao contributed equally to this study.;3. Department of Chemical Engineering, University of Massachusetts, Lowell, Lowell, Massachusetts, USA;4. Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA |
| Abstract: | |
| Keywords: | bacterial contamination capacitance CHO cell biomass conductivity contamination detection in-line probe real-time detection spike tests |