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Allelic variants of Ly-5 in inbred and natural populations of mice |
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| Authors: | Michael F Seldin Lawrence A D'Hoostelaere Alfred D Steinberg Yumiko Saga Herbert C Morse III |
| Institution: | (1) Cellular Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 20892 Bethesda, MD, USA;(2) Laboratory of Genetics, National Cancer Institute, National Institutes of Health, 20892, MD, USA;(3) Memorial Sloan Kettering Cancer Center, 10021 New York, NY, USA;(4) Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 20892 Bethesda, MD, USA |
| Abstract: | Allelic variants of Ly-5 in inbred commensal and other natural populations of mice were analyzed by patterns of restriction fragment length polymorphisms (RFLP) and Southern hybridization using an Ly-5 cDNA probe and by cell-surface staining with a panel of antibodies directed against polymorphic and nonpolymorphic Ly-5 determinants. New Ly-5 alleles were defined by RFLPs generated by both Eco RI and Bam HI restriction enzyme digests. The Mus musculus subspecies and other species within the genus Mus showed a strong correlation between allelic variants defined by restriction enzymes and serologic specificities. The data also suggest the conservation of the Ly-5 gene throughout the genus Mus. |
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