Chlorine transfer between glycine, taurine, and histamine: reaction rates and impact on cellular reactivity |
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Authors: | Peskin Alexander V Midwinter Robyn G Harwood David T Winterbourn Christine C |
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Institution: | Department of Pathology, Christchurch School of Medicine and Health Sciences, P.O. Box 4345, Christchurch, New Zealand. alexander.peskin@chmeds.ac.nz |
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Abstract: | Hypochlorous acid formed by activated neutrophils reacts with amines to produce chloramines. Chloramines vary in stability, reactivity, and cell permeability. We have examined whether chloramine exchange occurs between physiologically important amines or amino acids and if this affects interactions of chloramines with cells. We have demonstrated transchlorination reactions between histamine, glycine, and taurine chloramines by measuring chloramine decay rates with mixtures as well as by mass spectrometry. Kinetic analysis suggested the formation of an intermediate complex with a high Km. Apparent second-order rate constants, determined for concentrations
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