A new variant of human erythrocyte G6PD occurring at a high frequency amongst the population of two villages in The Gambia,West Africa |
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| Authors: | S G Welch I A McGregor K Williams |
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| Institution: | (1) Department of Biochemistry, The London Hospital Medical College, Turner Street, E1 2AD London, UK;(2) National Institute for Medical Research, Mill Hill, London, UK |
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| Abstract: | Summary During the course of a large survey of red cell G6PD genotypes in The Gambia, a slow electrophoretic variant with reduced enzyme activity was found to occur at a high frequency. This variant, G6PD Gambia, was found in the following genotypic combinations: males; G6PDGam, females; G6PDA+/Gam, G6PDB+/Gam, and G6PDA-/Gam. From the electrophoretic mobility and kinetic characteristics it was concluded that G6PD Gambia was a hitherto unreported variant of G6PD. The frequency of the G6PDGam gene amongst the 1109 individuals examined was 0.024. |
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