Mitogenic effects of staphylococcal antigenic substances on irradiated lymphocytes from Wistar rats |
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| Authors: | Kholodna L S Holeva O H Liubchenko T A Kucherenko M Ie |
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| Affiliation: | T.G. Shevchenko State University, Kyiv, Ukraine. |
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| Abstract: | Proliferation activity of lymphocytes from rats was studied using a micromethod of blasttransformation reaction after X-ray irradiation (absorbed doses for animals were 0.5 and 1 Gy). Staphylococcus protein A and peptidoglycan stimulated the proliferation of irradiated lymphocytes. It was assumed that staphylococcus antigen substances held radiation protective effects. Staphylococcus protein A may be used for stabilization of lymphopoesis and functional activity of humoral and cellular immunity in irradiated animals due to T- and B-mitogenic properties. |
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