Leptin interferes with 3',5'-Cyclic Adenosine Monophosphate (cAMP) signaling to inhibit steroidogenesis in human granulosa cells |
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| Authors: | Qing Lin Ling Song Poon Junling Chen Linan Cheng Basil HoYuen Peter CK Leung |
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| Institution: | (1) Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, V6H 3V, Canada;(2) Department of Obstetrics and Gynecology, Beijing Friendship Hospital-Affiliate of Capital University of Medical Sciences, Beijing, PR China;(3) School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, PR China |
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| Abstract: | Background Obesity has been linked to an increased risk of female infertility. Leptin, an adipocytokine which is elevated during obesity,
may influence gonadal function through modulating steroidogenesis in granulosa cells. |
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