Vanadate inhibits the production and/or release of secondary metabolites without impairing growth in several fungal species |
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Authors: | S Cehulová S Kryštofová V Betina L' Varečka |
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Institution: | (1) Department of Biochemistry and Microbiology, Slovak Technical University, 812 37 Bratislava, Slovak Republic |
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Abstract: | Vanadate (NaVO3) in concentrations between 0.1–3.0 mmol/L inhibited the production of secondary metabolites (SMs) of strains of the following
species:Trichoderma viride, Penicillium purpurogenum, Penicillium citrinum, Talaromyces avellaneus, andVerticillium psalliotœ. Growth was either not affected by NaVO3, or the inhibition of the SM production occurred at lower NaVO3, concentrations than that of the growth. Thus, at some NaVO3 concentration the SM production was inhibited but the growth remained unaffected. The results suggest that NaVO3 exerts a specific action either on the SM biosynthetic pathway(s) or on the export of SMs from cells. |
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