Genetic variants of fibroblast growth factor receptor 2 (<Emphasis Type="Italic">FGFR2</Emphasis>) are associated with breast cancer risk in Chinese women of the Han nationality |
| |
| Authors: | Fan?Chen Min?Lv Yun?Xue Jing?Zhou Feifei?Hu Xin?Chen Zhanqin?Zhao Yang?Li Email author" target="_blank">XingGuo?WangEmail author |
| |
| Institution: | (1) Life Sciences school of Hubei University, 368 Youyi Road, Wuchang, Wuhan, 430062, China;(2) Hainan Provincial Key Laboratory of Tropical Medicine, Hainan Medical College, Haikou, 571101, China;(3) Department of Medical Oncology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education, China), Peking University School of Oncology, Beijing Cancer Hospital and Institute, Fucheng Road 52, Haidian District, Beijing, 100142, China;(4) Lab of Medical Engineering, College of Medical Technology and Engineering, Henan University of Science and Techology, Luoyang, 471003, China;(5) Wuhan Tuberculosis Dispensary, 28 Baofeng Road, Qiaokou, Wuhan, 430030, China; |
| |
| Abstract: | Fibroblast growth factor receptor 2 (FGFR2), a recently described risk factor for breast cancer, plays important roles in cell growth, invasiveness, motility, and angiogenesis.
In attempt to investigate whether FGFR2 polymorphisms are associated with a risk of breast cancer in Chinese women of the Han nationality, we genotyped single-nucleotide
polymorphisms (SNPs) of seven FGFR2 sites (rs2981582, rs17102287, rs17542768, rs10510097, rs11200012, rs3750817, rs2981578) in 816 women including 388 breast
cancer patients and 428 healthy controls via the polymerase chain reaction single-strand conformation polymorphism procedure
as well as sequence detection. Our results suggest that the A allele and AA genotype of SNP rs2981578 appear to be protective
factors associated with breast cancer, while the CT genotype of SNP rs3750817 is a putative risk factor. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
