MCM-GINS and MCM-MCM interactions in vivo visualised by bimolecular fluorescence complementation in fission yeast |
| |
| Authors: | Gökhan Akman Stuart A MacNeill |
| |
| Affiliation: | 1. Department of Biology, University of Copenhagen, Copenhagen Biocenter, Ole Maal?es Vej 5, 2200, Copenhagen, Denmark
2. Centre for Biomolecular Sciences, University of St Andrews, St Andrews, North Haugh, Fife KY16 9ST, UK
|
| |
| Abstract: | ![]()
Background Each of the three individual components of the CMG complex (Cdc45, MCM and GINS) is essential for chromosomal DNA replication in eukaryotic cells, both for the initiation of replication at origins and also for normal replication fork progression. The MCM complex is a DNA helicase that most likely functions as the catalytic core of the replicative helicase, unwinding the parental duplex DNA ahead of the moving replication fork, whereas Cdc45 and the GINS complex are believed to act as accessory factors for MCM. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
