| 细胞核内RNA干扰途径研究进展 |
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| 引用本文： | 骆继怀,独军政,常惠芸.细胞核内RNA干扰途径研究进展[J].生物技术通讯,2011,22(3):437-441. |
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| 作者姓名： | 骆继怀 独军政 常惠芸 |
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| 作者单位： | 中国农业科学院,兰州兽医研究所,家畜疫病病原生物学国家重点实验室,农业部畜禽病毒学重点开放实验室,国家口蹄疫参考实验室,甘肃,兰州,730046 |
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| 摘 要： | RNA干扰(RNAi)是双链RNA分子在mRNA水平关闭相应序列基因表达的过程。RNAi的分子机制及功能仍然有待深入研究与阐明,但已经在基因组结构与功能研究中得到广泛运用。我们简要综述RNAi的作用机制,及已发现的细胞核内干扰途径——RNA指导的DNA甲基化、异染色质、DNA切除和减数分裂性沉默等相关研究进展。
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| 关 键 词： | RNA干扰 RNA指导的DNA甲基化 异染色质 DNA切除 减数分裂性沉默 |
Advance of RNA Interference Pathways in the Nucleus |
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| LUO Ji-Huai,DU Jun-Zheng,CHANG Hui-Yun.Advance of RNA Interference Pathways in the Nucleus[J].Letters in Biotechnology,2011,22(3):437-441. |
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| Authors: | LUO Ji-Huai DU Jun-Zheng CHANG Hui-Yun |
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| Institution: | State Key Laboratory of Veterinary Etiological Biology,National Foot and Mouth Disease Reference Laboratory,Key Laboratory of Animal Virology of Ministry of Agriculture,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730046,China |
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| Abstract: | RNA interference（RNAi） is the process whereby double-stranded RNA（dsRNA） induces the homology-dependent degradation or translational gene silencing of cognate mRNA.At present,although there is more to RNAi than we can yet fathom,it has been extensively used as tool to explore gene function and structure.Here we wish to review the mechanism of RNAi and its nucleus interference channels of RNA directed DNA methylation,heterochromatin,DNA resection and meiotic silencing. |
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| Keywords: | RNA interference RNA-directed DNA methylation heterochromatin DNA excision meiotic silencing |
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