Directional Modifications of Resibufogenin by Mucor subtilissimus and Pseudomonas aeruginosa |
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| Authors: | Jixun Zhan Yuanxing Zhang Wenhui Liu Hongzhu Guo Dean Guo |
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| Affiliation: | a State Key Laboratory of Bioreactor Engineering East China University of Science and Technology 200237 Shanghai.b State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences, Peking University 100083 Beijing. |
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| Abstract: | Directional modifications of resibufogenin 1 by Mucor subtilissimus and Pseudomonas aeruginosa were carried out. The substrate was hydroxylated at C-12 by M. subtilissimus AS 3.2454, from which a major product 12-hydroxyresibufogenin 2 was obtained. Then product 2 was dehydrogenated by P. aeruginosa AS 1.860, which resulted in a new compound 12β-hydroxy-3-keto-resibufogenin 3. |
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| Keywords: | Directional Modifications Resibufogenin Hydroxylation Mucor Subtilissimus Dehydrogenation Pseudomonas Aeruginosa |
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