QSAR study of quinolinediones with inhibitory activity of endothelium-dependent vasorelaxation by CoMSIA |
| |
| Authors: | Choo Hea-Young Park Choi Suyoung Ryu Chung-Kyu Kim Hwa-Jung Lee In Young Paeb Ae Nim Koh Hun Yeong |
| |
| Affiliation: | School of Pharmacy, Ewha Womans University, Seoul 120-750, South Korea. hypark@mm.ewha.ac.kr |
| |
| Abstract: | 
The 3D-QSAR study of quinolinediones which showed potent inhibitory effect on the acetylcholine induced vasorelaxation of rat aorta with the endothelium was conducted by CoMSIA. The statistical result, cross-validated q(2) (0.741) and r(2) (0.960) values, gave reliability to the prediction of inhibitory activity of this series. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
