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Vaccine-Induced Linear Epitope-Specific Antibodies to Simian Immunodeficiency Virus SIVmac239 Envelope Are Distinct from Those Induced to the Human Immunodeficiency Virus Type 1 Envelope in Nonhuman Primates |
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| Authors: | Xiaoying Shen Ryan Duffy Robert Howington Alethea Cope Shanmugalakshmi Sadagopal Haesun Park Ranajit Pal Suefen Kwa Song Ding Otto O. Yang Genevieve G. Fouda Roger Le Grand Diane Bolton Mariano Esteban Sanjay Phogat Mario Roederer Rama R. Amara Louis J. Picker Robert A. Seder M. Juliana McElrath Susan Barnett Sallie R. Permar Robin Shattock Anthony L. DeVico Barbara K. Felber George N. Pavlakis Giuseppe Pantaleo Bette T. Korber David C. Montefiori Georgia D. Tomaras |
| Abstract: | To evaluate antibody specificities induced by simian immunodeficiency virus (SIV) versus human immunodeficiency virus type 1 (HIV-1) envelope antigens in nonhuman primate (NHP), we profiled binding antibody responses to linear epitopes in NHP studies with HIV-1 or SIV immunogens. We found that, overall, HIV-1 Env IgG responses were dominated by V3, with the notable exception of the responses to the vaccine strain A244 Env that were dominated by V2, whereas the anti-SIVmac239 Env responses were dominated by V2 regardless of the vaccine regimen. |
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