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Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits
Authors:Sara Marie Katrancha  Juliana E. Shaw  Amy Y. Zhao  Samuel A. Myers  Alexandra R. Cocco  Amanda T. Jeng  Minsheng Zhu  Christopher Pittenger  Charles A. Greer  Steven A. Carr  Xiao Xiao  Anthony J. Koleske
Affiliation:1. Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06510, USA;2. Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06510, USA;3. Department of Neuroscience, Yale University, New Haven, CT 06510, USA;4. The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;5. Model Animal Research Center, Nanjing University, Nanjing 210061, China;6. Department of Psychiatry, Yale University, New Haven, CT 06510, USA;7. Child Study Center, Yale University, New Haven, CT 06510, USA;8. Department of Neurosurgery, Yale University, New Haven, CT 06510, USA;9. Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China;10. Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai 200433, China
Abstract:
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  • Keywords:TRIO  triple functional domain protein  neurodevelopmental disorder  haploinsufficiency  dendritic spine  anxiety  social preference  motor cortex  long-term potentiation  phosphodiesterase 4A5
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