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Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits
Authors:Sara Marie Katrancha  Juliana E Shaw  Amy Y Zhao  Samuel A Myers  Alexandra R Cocco  Amanda T Jeng  Minsheng Zhu  Christopher Pittenger  Charles A Greer  Steven A Carr  Xiao Xiao  Anthony J Koleske
Institution:1. Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06510, USA;2. Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06510, USA;3. Department of Neuroscience, Yale University, New Haven, CT 06510, USA;4. The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;5. Model Animal Research Center, Nanjing University, Nanjing 210061, China;6. Department of Psychiatry, Yale University, New Haven, CT 06510, USA;7. Child Study Center, Yale University, New Haven, CT 06510, USA;8. Department of Neurosurgery, Yale University, New Haven, CT 06510, USA;9. Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai 200433, China;10. Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai 200433, China
Abstract:
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  • Keywords:TRIO  triple functional domain protein  neurodevelopmental disorder  haploinsufficiency  dendritic spine  anxiety  social preference  motor cortex  long-term potentiation  phosphodiesterase 4A5
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