Protein microarrays and their applications |
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Authors: | Email author" target="_blank">Bum?Hwan?LeeEmail author Teruyuki?Nagamune |
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Institution: | (1) Digital Bio Technology, 440-301 Kyonggi, Korea;(2) Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 113-8656 Tokyo, Japan |
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Abstract: | In recent years, the importance of proteomic works, such as protein expression, detection and identification, has grown in
the fields of proteomic and diagnostic research. This is because complete genome sequences of humans, and other organisms,
progress as cellular processing and controlling are performed by proteins as well as DNA or RNA. However, conventional protein
analyses are time-consuming; therefore, high throughput protein analysis methods, which allow fast, direct and quantitative
detection, are needed. These are so-called protein microarrays or protein chips, which have been developed to fulfill the
need for high-throughput protein analyses. Although protein arrays are still in their infancy, technical development in immobilizing
proteins in their native conformation on arrays, and the development of more sensitive detection methods, will facilitate
the rapid deployment of protein arrays as high-throughput protein assay tools in proteomics and diagnostics. This review summarizes
the basic technologies that are needed in the fabrication of protein arrays and their recent applications. |
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Keywords: | protein microarray immunoassay diagnostics proteomics |
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