Biomarkers for Ilex pubescens under anti-platelet activity-oriented isolation |
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| Institution: | 1. Laboratory of Enzyme Technology, Department of Biotechnology, School of Food, Biotechnology and Development, Agricultural University of Athens, 75 Iera Odos Street, GR-11855 Athens, Greece;2. Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942 Alkharj, KSA, Saudi Arabia;3. Department of Microbiology, College of Science, Al-Azhar University, Nasr City, 11884 Cairo, Egypt;4. Department of Pharmacognosy, College of Pharmacy, Alexandria University, Alexandria 21215, Egypt |
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| Abstract: | In the present study, eleven ursane triterpenoids (1—11), seven oleanane triterpenoids (12—18), one lupine sapogenin (19) as well as two sterols (20 and 21) were obtained from Ilex pubescens under the anti-platelet activity-oriented isolation. Among them, compounds 2 and 4 were isolated from I. pubescens for the first time, while the isolation of the compounds 12, 15, 16 and 17 was a new finding in the Aquifoliaceae family. Our present study exhibited the taxonomic relationships (similarities and differences) between I. pubescens and some other species of genus Ilex. The result also suggested that triterpenoids are the anti-platelet components which may be fingerprints and serve as biomarkers for seeking alternative sources for I. pubescens. |
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| Keywords: | Aquifoliaceae Triterpenoid Anti-platelet activity-oriented isolation Chemotaxonomy |
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