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Inhibitors of hepatitis C virus NS3.4A protease 2. Warhead SAR and optimization |
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| Authors: | Perni Robert B Pitlik Janos Britt Shawn D Court John J Courtney Lawrence F Deininger David D Farmer Luc J Gates Cynthia A Harbeson Scott L Levin Rhonda B Lin Chao Lin Kai Moon Young-Choon Luong Yu-Ping O'Malley Ethan T Rao B Govinda Thomson John A Tung Roger D Van Drie John H Wei Yunyi |
| Affiliation: | Vertex Pharmaceuticals Inc., 130 Waverly Street, Cambridge, MA 02139, USA. |
| Abstract: | The alpha-ketoamide warhead (e.g., 15) was found to be a practical replacement for aliphatic aldehydes in a series of HCV NS3.4A protease inhibitors. Structure-activity relationships and prime side optimization are discussed. |
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